Johns Hopkins Center for Communication Programs (CCP) has implemented the COVID-19 vaccine promotion project in Ethiopia with funding and support from the United States Agency for International Development (USAID) through the Global Breakthrough ACTION mechanism. CCP/Ethiopia conducted a cross-sectional community-based assessment of community health workers’ (CHWs) hesitancy toward COVID-19 vaccines during June and July 2022. CHWs include both Health Extension Workers (HEWs) and Women Development Army (WDA). The assessment aimed to inform risk communication and vaccine promotion programs in Ethiopia. Face-to-face interviews were used to collect information from CHWs regarding exposure to messages about COVID-19 vaccines, risk perceptions and practices related to COVID-19 vaccines. A total of 998 randomly sampled CHWs (491 HEWs and 507 WDAs) were interviewed in five clusters of major regions of Ethiopia (Amhara, Oromia, Benishangul-Gumuz, Southern Nations and Nationalities Peoples Region, Dire Dawa). About 200 randomly sampled CHWs were interviewed from each cluster.