Johns Hopkins Center for Communication Programs (CCP) has implemented a COVID-19 vaccine promotion project in Ethiopia with funding and technical assistance from the United States Agency for International Development (USAID) through the global Breakthrough ACTION mechanism. From February to March 2022, CCP/Ethiopia conducted a cross-sectional facility-based assessment of COVD-19 vaccine hesitancy among healthcare workers (HCWs). The assessment aimed to inform the risk communication and vaccine promotion programs in Ethiopia. Mobile phone assisted interviews were used to collect information regarding exposure to COVID-19 messages, risk perceptions and behavioral practices that are relevant to COVID-19 vaccines. A total of 500 randomly sampled healthcare workers were interviewed from selected health centers and hospitals in five clusters of major regions of Ethiopia (Bahir Dar, Hawasa, Jimma, Assossa and Addis Ababa). About 100 randomly sampled HCWs were interviewed from each cluster.