Côte d’Ivoire has recorded 87,966 confirmed COVID-19 cases, 87,129 recovered and 833 deaths and 25,263,932 doses administered, and 59% vaccination target coverage (as of 02/09/23, MSHPCMU). Eligible for the vaccine since the start of vaccination in Côte d’Ivoire, 9% of carriers of chronic pathologies have received at least one dose and 5% have been completely vaccinated (Point of 09/02/23, MSHPCMU). The Breakthrough ACTION project through USAID funding, supports the government of Côte d’Ivoire through social and behavior change (SBC) interventions, including research and monitoring to inform COVID-19 vaccination activities. Breakthrough ACTION collected qualitative data across three sites (Abidjan – Bouaké – San Pedro) to assess perceptions of the COVID-19 vaccine. This analysis focuses on the perceptions of COVID-19 among people living with a comorbidity (diabetes, hypertension, obesity, HIV, etc.).