The COVID-19 pandemic has exacerbated psychological and economic distress in many countries around the world, causing existing health and socioeconomic inequities to worsen. In low- and middle-income countries (LMICs), people have reported increased symptoms of anxiety and depression in addition to economic adversity. Understanding the extent of pandemic-related psychological and economic distress in LMICs can inform the planning and provision of mental health and social support services in the near term as well as strategies for the continuation of mental health and social protection programs post-pandemic. This research brief presents trends in reported nervousness, depression, food insecurity, and financial insecurity in 21 LMICs from June through September 2021.